Another scientific publication highlighting the need to strengthen chemical monitoring efforts

A newly published international study has brought renewed attention to the widespread presence of antifungal compounds in natural and urban environments. Drawing on an extensive review of scientific literature, the research explores how these substances enter waterways, accumulate in soils, and potentially contribute to the development of antifungal resistance.

According to the authors, antifungal agents - commonly used in medicine, agriculture, and various personal care products - are increasingly being detected in wastewater, surface water, and sewage sludge. The study notes that conventional wastewater treatment plants are not designed to fully remove these compounds, resulting in their release into the environment.

The research team analysed data from multiple countries and environmental systems, identifying dozens of antifungal compounds, particularly azoles, as frequent contaminants. Some were found at notably high concentrations, underscoring concerns about long-term environmental exposure and ecosystem impacts.

A key contribution of the study is the proposal of Predicted No-Effect Concentrations (PNECs) for several antifungal compounds. These values, based on microbiological susceptibility data, are intended to help regulators and environmental agencies define safe thresholds and prioritise monitoring efforts.

The authors also highlight the need for improved wastewater treatment technologies, expanded environmental monitoring, and coordinated international action to prevent further dissemination of antifungal agents and mitigate associated resistance risks.

With global antifungal use continuing to rise, the findings serve as a timely reminder of the interconnectedness of environmental and public health challenges, reinforcing the importance of a One Health perspective.

Please find the paper here: https://doi.org/10.3389/ftox.2026.1767925